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==Crystal Structure of Sugar Transaminase from Klebsiella pneumoniae Complexed with PLP==
==Crystal Structure of Sugar Transaminase from Klebsiella pneumoniae Complexed with PLP==
<StructureSection load='6blg' size='340' side='right' caption='[[6blg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6blg' size='340' side='right'caption='[[6blg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6blg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLG FirstGlance]. <br>
<table><tr><td colspan='2'>[[6blg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_MGH_78578 Klebsiella pneumoniae subsp. pneumoniae MGH 78578]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BLG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.102&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-4-amino-4,6-dideoxygalactose_transaminase dTDP-4-amino-4,6-dideoxygalactose transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.59 2.6.1.59] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6blg OCA], [https://pdbe.org/6blg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6blg RCSB], [https://www.ebi.ac.uk/pdbsum/6blg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6blg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6blg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6blg OCA], [http://pdbe.org/6blg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6blg RCSB], [http://www.ebi.ac.uk/pdbsum/6blg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6blg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A6TGH9_KLEP7 A6TGH9_KLEP7]] Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.[HAMAP-Rule:MF_02026]  
[https://www.uniprot.org/uniprot/A6TGH9_KLEP7 A6TGH9_KLEP7] Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.[HAMAP-Rule:MF_02026]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DTDP-4-amino-4,6-dideoxygalactose transaminase]]
[[Category: Klebsiella pneumoniae subsp. pneumoniae MGH 78578]]
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Maltseva, N]]
[[Category: Maltseva N]]
[[Category: Shatsman, S]]
[[Category: Shatsman S]]
[[Category: Csgid]]
[[Category: Transferase]]

Latest revision as of 14:45, 4 October 2023

Crystal Structure of Sugar Transaminase from Klebsiella pneumoniae Complexed with PLP

6blg, resolution 2.10Å

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