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==X-ray crystal structural analysis of the complex between ALG-2 and Sec31A peptide==
==X-ray crystal structural analysis of the complex between ALG-2 and Sec31A peptide==
<StructureSection load='3wxa' size='340' side='right' caption='[[3wxa]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
<StructureSection load='3wxa' size='340' side='right'caption='[[3wxa]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wxa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WXA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDCD6, ALG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxa OCA], [http://pdbe.org/3wxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wxa RCSB], [http://www.ebi.ac.uk/pdbsum/3wxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxa OCA], [https://pdbe.org/3wxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wxa RCSB], [https://www.ebi.ac.uk/pdbsum/3wxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wxa ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/SC31A_HUMAN SC31A_HUMAN]] A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref> [[http://www.uniprot.org/uniprot/SC31A_HUMAN SC31A_HUMAN]] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
[https://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3wxa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3wxa" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Kawasaki, M]]
[[Category: Large Structures]]
[[Category: Maki, M]]
[[Category: Kawasaki M]]
[[Category: Shibata, H]]
[[Category: Maki M]]
[[Category: Suzuki, H]]
[[Category: Shibata H]]
[[Category: Takahashi, T]]
[[Category: Suzuki H]]
[[Category: Wakatsuki, S]]
[[Category: Takahashi T]]
[[Category: Apoptosis]]
[[Category: Wakatsuki S]]
[[Category: Apoptosis-transport protein complex]]
[[Category: Calcium binding]]
[[Category: Endoplasmic reticulum]]
[[Category: Membrane]]
[[Category: Penta-ef-hand protein]]
[[Category: Transport]]
Retrieved from "https://proteopedia.org/3wxa"