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==Crystal structure of RORc in complex with a partial inverse agonist compound==
==Crystal structure of RORc in complex with a partial inverse agonist compound==
<StructureSection load='4wlb' size='340' side='right' caption='[[4wlb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4wlb' size='340' side='right'caption='[[4wlb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wlb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WLB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wlb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WLB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QQ:N-(4-FLUOROBENZYL)-N-(2-METHYLPROPYL)-6-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIDINE-3-SULFONAMIDE'>3QQ</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QQ:N-(4-FLUOROBENZYL)-N-(2-METHYLPROPYL)-6-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIDINE-3-SULFONAMIDE'>3QQ</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wlb OCA], [http://pdbe.org/4wlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wlb RCSB], [http://www.ebi.ac.uk/pdbsum/4wlb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wlb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wlb OCA], [https://pdbe.org/4wlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wlb RCSB], [https://www.ebi.ac.uk/pdbsum/4wlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wlb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.  
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Boenig, G]]
[[Category: Large Structures]]
[[Category: Hymowitz, S G]]
[[Category: Boenig G]]
[[Category: Kiefer, J R]]
[[Category: Hymowitz SG]]
[[Category: Nuclear receptor ligand binding domain]]
[[Category: Kiefer JR]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4wlb"