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==The Structure of human Argonaute-1 in complex with the hook motif of human GW182==
==The Structure of human Argonaute-1 in complex with the hook motif of human GW182==
<StructureSection load='5w6v' size='340' side='right' caption='[[5w6v]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
<StructureSection load='5w6v' size='340' side='right'caption='[[5w6v]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5w6v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W6V FirstGlance]. <br>
<table><tr><td colspan='2'>[[5w6v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W6V FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.828&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGO1, EIF2C1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TNRC6A, CAGH26, KIAA1460, TNRC6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w6v OCA], [https://pdbe.org/5w6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w6v RCSB], [https://www.ebi.ac.uk/pdbsum/5w6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w6v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w6v OCA], [http://pdbe.org/5w6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w6v RCSB], [http://www.ebi.ac.uk/pdbsum/5w6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w6v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref> [[http://www.uniprot.org/uniprot/TNR6A_HUMAN TNR6A_HUMAN]] Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.<ref>PMID:16284622</ref> <ref>PMID:16284623</ref> <ref>PMID:17596515</ref> <ref>PMID:17671087</ref> <ref>PMID:19056672</ref> <ref>PMID:19304925</ref> 
[https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5w6v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5w6v" style="background-color:#fffaf0;"></div>
==See Also==
*[[Argonaute 3D structures|Argonaute 3D structures]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Spodoptera frugiperda]]
[[Category: Spodoptera frugiperda]]
[[Category: Elkayam, E]]
[[Category: Elkayam E]]
[[Category: Faehnle, C R]]
[[Category: Faehnle CR]]
[[Category: Joshua-Tor, L]]
[[Category: Joshua-Tor L]]
[[Category: Gene regulation-rna complex]]
[[Category: Gw motif]]
[[Category: Rna binding protein]]
[[Category: Rna interference]]
Retrieved from "https://proteopedia.org/5w6v"