6bo2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 6bo2 is ON HOLD Authors: Sullivan, M.P., Hartinger, C.G., Goldstone, D.C. Description: Ruthenium(II)(1,3-dimethylbenzimidazol-2-ylidene)(chlorido)2... |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Adducts formed after 1 month in the reaction of dichlorido(1,3-dimethylbenzimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL== | |||
<StructureSection load='6bo2' size='340' side='right'caption='[[6bo2]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BO2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E3D:bis(chloranyl)-(1,3-dimethylbenzimidazol-3-ium-2-yl)ruthenium'>E3D</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo2 OCA], [https://pdbe.org/6bo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bo2 RCSB], [https://www.ebi.ac.uk/pdbsum/6bo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(eta6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre. | |||
Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.,Sullivan MP, Nieuwoudt MK, Bowmaker GA, Lam NYS, Truong D, Goldstone DC, Hartinger CG Chem Commun (Camb). 2018 May 1. doi: 10.1039/c8cc02433b. PMID:29713703<ref>PMID:29713703</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6bo2" style="background-color:#fffaf0;"></div> | ||
[[Category: Goldstone | |||
[[Category: Hartinger | ==See Also== | ||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | |||
[[Category: Large Structures]] | |||
[[Category: Goldstone DC]] | |||
[[Category: Hartinger CG]] | |||
[[Category: Sullivan MP]] | |||
Latest revision as of 13:02, 13 August 2026
Adducts formed after 1 month in the reaction of dichlorido(1,3-dimethylbenzimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL
| ||||||||||||
