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==NMR STUDY OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN==
==NMR STUDY OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN==
<StructureSection load='3ifb' size='340' side='right' caption='[[3ifb]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='3ifb' size='340' side='right'caption='[[3ifb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ifb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IFB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ifb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFB FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ifb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifb OCA], [http://pdbe.org/3ifb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ifb RCSB], [http://www.ebi.ac.uk/pdbsum/3ifb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifb OCA], [https://pdbe.org/3ifb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifb RCSB], [https://www.ebi.ac.uk/pdbsum/3ifb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FABPI_HUMAN FABPI_HUMAN]] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.  
[https://www.uniprot.org/uniprot/FABPI_HUMAN FABPI_HUMAN] FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifb_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifb_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3ifb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ifb" style="background-color:#fffaf0;"></div>
==See Also==
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Baier, L J]]
[[Category: Large Structures]]
[[Category: Hamilton, J A]]
[[Category: Baier LJ]]
[[Category: Luecke, C]]
[[Category: Hamilton JA]]
[[Category: Sacchettini, J C]]
[[Category: Luecke C]]
[[Category: Zhang, F]]
[[Category: Sacchettini JC]]
[[Category: Fatty acid binding]]
[[Category: Zhang F]]
[[Category: Fatty acid binding protein]]
[[Category: Intracellular lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Single base polymorphism]]
Retrieved from "https://proteopedia.org/3ifb"