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==CRYSTAL STRUCTURE OF AN ENGINEERED CRO MONOMER BOUND NONSPECIFICALLY TO DNA==
==CRYSTAL STRUCTURE OF AN ENGINEERED CRO MONOMER BOUND NONSPECIFICALLY TO DNA==
<StructureSection load='3orc' size='340' side='right' caption='[[3orc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3orc' size='340' side='right'caption='[[3orc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3orc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_lambda Bacteriophage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ORC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3orc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3orc OCA], [http://pdbe.org/3orc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3orc RCSB], [http://www.ebi.ac.uk/pdbsum/3orc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3orc ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3orc OCA], [https://pdbe.org/3orc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3orc RCSB], [https://www.ebi.ac.uk/pdbsum/3orc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3orc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD]] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.  
[https://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/3orc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/3orc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacteriophage lambda]]
[[Category: Escherichia virus Lambda]]
[[Category: Albright, R A]]
[[Category: Large Structures]]
[[Category: Matthews, B W]]
[[Category: Albright RA]]
[[Category: Mossing, M C]]
[[Category: Matthews BW]]
[[Category: Cro]]
[[Category: Mossing MC]]
[[Category: Gene regulation-dna complex]]
[[Category: Helix-turn-helix]]
[[Category: Monomer-dimer]]
[[Category: Protein-dna interaction]]
[[Category: Repressor]]
Retrieved from "https://proteopedia.org/3orc"