3zgl: Difference between revisions
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==Crystal structures of Escherichia coli IspH in complex with AMBPP a potent inhibitor of the methylerythritol phosphate pathway== | ==Crystal structures of Escherichia coli IspH in complex with AMBPP a potent inhibitor of the methylerythritol phosphate pathway== | ||
<StructureSection load='3zgl' size='340' side='right' caption='[[3zgl]], [[Resolution|resolution]] 1.68Å' scene=''> | <StructureSection load='3zgl' size='340' side='right'caption='[[3zgl]], [[Resolution|resolution]] 1.68Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zgl]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3zgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10E:(2E)-4-AMINO-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10E</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgl OCA], [https://pdbe.org/3zgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgl RCSB], [https://www.ebi.ac.uk/pdbsum/3zgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3zgl" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3zgl" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Barbier | [[Category: Barbier E]] | ||
[[Category: Borel | [[Category: Borel F]] | ||
[[Category: | [[Category: Dale Poulter C]] | ||
[[Category: | [[Category: Ferrer JL]] | ||
[[Category: | [[Category: Janthawornpong K]] | ||
[[Category: | [[Category: Kratsutsky S]] | ||
[[Category: Rohmer | [[Category: Rohmer M]] | ||
[[Category: Seemann | [[Category: Seemann M]] | ||
Latest revision as of 17:49, 8 September 2026
Crystal structures of Escherichia coli IspH in complex with AMBPP a potent inhibitor of the methylerythritol phosphate pathway
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