5lja: Difference between revisions

<StructureSection load='5lja' size='340' side='right'caption='[[5lja]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[5lja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LJA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lja OCA], [https://pdbe.org/5lja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lja RCSB], [https://www.ebi.ac.uk/pdbsum/5lja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lja ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MACB_ECOLI MACB_ECOLI] Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid.<ref>PMID:11544226</ref> <ref>PMID:17214741</ref> <ref>PMID:18955484</ref> <ref>PMID:23974027</ref>  

[[Category: Escherichia coli K-12]]

[[Category: Large Structures]]

[[Category: Crow A]]