1cb5: Difference between revisions

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==HUMAN BLEOMYCIN HYDROLASE.==
==HUMAN BLEOMYCIN HYDROLASE.==
<StructureSection load='1cb5' size='340' side='right' caption='[[1cb5]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='1cb5' size='340' side='right'caption='[[1cb5]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1cb5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CB5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1cb5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CB5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cb5 OCA], [http://pdbe.org/1cb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1cb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cb5 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cb5 OCA], [https://pdbe.org/1cb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1cb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cb5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BLMH_HUMAN BLMH_HUMAN]] The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity).  
[https://www.uniprot.org/uniprot/BLMH_HUMAN BLMH_HUMAN] The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/1cb5_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/1cb5_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Farrell, P A.O]]
[[Category: Large Structures]]
[[Category: Gonzalez, F]]
[[Category: Gonzalez F]]
[[Category: Johnston, S A]]
[[Category: Johnston SA]]
[[Category: Joshua-Tor, L]]
[[Category: Joshua-Tor L]]
[[Category: Zheng, W]]
[[Category: O'Farrell PA]]
[[Category: Aminopeptidase]]
[[Category: Zheng W]]
[[Category: Bleomycin]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]
[[Category: Self-compartmentalizing]]
Retrieved from "https://proteopedia.org/1cb5"