6br2: Difference between revisions
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==Structure of RORgt in complex with a novel isoquinoline inverse agonist.== | |||
<StructureSection load='6br2' size='340' side='right'caption='[[6br2]], [[Resolution|resolution]] 3.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6br2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BR2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E3S:(1R)-N-(4-tert-butyl-3-fluorophenyl)-6-methoxy-2-[(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxamide'>E3S</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
[[Category: Hoffman | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6br2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6br2 OCA], [https://pdbe.org/6br2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6br2 RCSB], [https://www.ebi.ac.uk/pdbsum/6br2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6br2 ProSAT]</span></td></tr> | ||
[[Category: Skene | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hoffman I]] | |||
[[Category: Skene RJ]] | |||
Latest revision as of 14:23, 13 March 2024
Structure of RORgt in complex with a novel isoquinoline inverse agonist.
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