6f09: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 6f09 is ON HOLD  until Paper Publication
==Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide==
<StructureSection load='6f09' size='340' side='right'caption='[[6f09]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6f09]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F09 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.594&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f09 OCA], [https://pdbe.org/6f09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f09 RCSB], [https://www.ebi.ac.uk/pdbsum/6f09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f09 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ubiquitin-specific protease 8 (USP8)/14-3-3 protein-protein interaction has recently been shown to exert a significant role in the pathogenesis of Cushing's disease (CD). USP8 is a deubiquitinase that prevents epidermal growth factor receptor (EGFR) degradation. Impairment of 14-3-3 binding leads to a higher deubiquitination of EGFR and results in a higher EGFR signaling and an increased production of adrenocorticotropic hormone. Here we report the high-resolution crystal structure of the 14-3-3 binding motif of USP8 surrounding Ser718 in complex with 14-3-3zeta and characterize the interaction with fluorescence polarization and isothermal titration calorimetry. Furthermore, we analyze the effect of USP8 mutations identified in CD on binding to 14-3-3.


Authors: Centorrino, F., Ballone, A., Ottmann, C., Guo, S., Leysen, S.
Biophysical and structural insight into the USP8/14-3-3 interaction.,Centorrino F, Ballone A, Wolter M, Ottmann C FEBS Lett. 2018 Feb 23. doi: 10.1002/1873-3468.13017. PMID:29473952<ref>PMID:29473952</ref>


Description: Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Ottmann, C]]
<div class="pdbe-citations 6f09" style="background-color:#fffaf0;"></div>
[[Category: Ballone, A]]
 
[[Category: Guo, S]]
==See Also==
[[Category: Centorrino, F]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
[[Category: Leysen, S]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ballone A]]
[[Category: Centorrino F]]
[[Category: Guo S]]
[[Category: Leysen S]]
[[Category: Ottmann C]]
Retrieved from "https://proteopedia.org/6f09"