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==E. coli LptB in complex with ADP and a novobiocin derivative==
==E. coli LptB in complex with ADP and a novobiocin derivative==
<StructureSection load='6b8b' size='340' side='right' caption='[[6b8b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6b8b' size='340' side='right'caption='[[6b8b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6b8b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8B FirstGlance]. <br>
<table><tr><td colspan='2'>[[6b8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B8B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CZJ:(3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide'>CZJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b89|6b89]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CZJ:(3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-ben+zopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide'>CZJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8b OCA], [http://pdbe.org/6b8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8b RCSB], [http://www.ebi.ac.uk/pdbsum/6b8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8b OCA], [https://pdbe.org/6b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b8b RCSB], [https://www.ebi.ac.uk/pdbsum/6b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LPTB_ECOLI LPTB_ECOLI]] Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.<ref>PMID:16765569</ref> <ref>PMID:17056748</ref> <ref>PMID:18424520</ref>
[https://www.uniprot.org/uniprot/LPTB_ECOLI LPTB_ECOLI] Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.<ref>PMID:16765569</ref> <ref>PMID:17056748</ref> <ref>PMID:18424520</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kahne, D K]]
[[Category: Escherichia coli K-12]]
[[Category: Lazarus, M D]]
[[Category: Large Structures]]
[[Category: Mandler, M D]]
[[Category: Kahne DK]]
[[Category: May, J M]]
[[Category: Lazarus MB]]
[[Category: Owens, T W]]
[[Category: Mandler MD]]
[[Category: Abc transporter]]
[[Category: May JM]]
[[Category: Lipid transport]]
[[Category: Owens TW]]
[[Category: Lipid transport-activator complex]]
[[Category: Lps transport]]
[[Category: Lptb]]
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