2c4m: Difference between revisions

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[[Image:2c4m.gif|left|200px]]


{{Structure
==Starch phosphorylase: structural studies explain oxyanion-dependent kinetic stability and regulatory control.==
|PDB= 2c4m |SIZE=350|CAPTION= <scene name='initialview01'>2c4m</scene>, resolution 1.9&Aring;
<StructureSection load='2c4m' size='340' side='right'caption='[[2c4m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[2c4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_callunae Corynebacterium callunae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4M FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4m OCA], [https://pdbe.org/2c4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4m RCSB], [https://www.ebi.ac.uk/pdbsum/2c4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4m ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4m OCA], [http://www.ebi.ac.uk/pdbsum/2c4m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c4m RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q8KQ56_9CORY Q8KQ56_9CORY] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.[RuleBase:RU000587]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c4m_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4m ConSurf].
<div style="clear:both"></div>


'''STARCH PHOSPHORYLASE: STRUCTURAL STUDIES EXPLAIN OXYANION-DEPENDENT KINETIC STABILITY AND REGULATORY CONTROL.'''
==See Also==
 
*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2C4M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_callunae Corynebacterium callunae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4M OCA].
[[Category: Corynebacterium callunae]]
[[Category: Corynebacterium callunae]]
[[Category: Phosphorylase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Nidetzky B]]
[[Category: Nidetzky, B.]]
[[Category: Purvis A]]
[[Category: Purvis, A.]]
[[Category: Watson K]]
[[Category: Watson, K.]]
[[Category: allosteric control]]
[[Category: glycosyltransferase]]
[[Category: phosphate dependence]]
[[Category: phosphorylase]]
[[Category: starch degrading]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:13 2008''

Latest revision as of 14:05, 13 December 2023

Starch phosphorylase: structural studies explain oxyanion-dependent kinetic stability and regulatory control.

2c4m, resolution 1.90Å

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