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==Impact of IR active probes on PDZ3 and its ligand binding studied by NMR and X-ray crystallography==
==Impact of IR active probes on PDZ3 and its ligand binding studied by NMR and X-ray crystallography==
<StructureSection load='5w72' size='340' side='right' caption='[[5w72]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5w72' size='340' side='right'caption='[[5w72]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5w72]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W72 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5w72]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W72 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZH:AZIDOHOMOALANINE'>AZH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w72 OCA], [http://pdbe.org/5w72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w72 RCSB], [http://www.ebi.ac.uk/pdbsum/5w72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w72 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZH:AZIDOHOMOALANINE'>AZH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w72 OCA], [https://pdbe.org/5w72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w72 RCSB], [https://www.ebi.ac.uk/pdbsum/5w72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w72 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5w72" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5w72" style="background-color:#fffaf0;"></div>
==See Also==
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kudlinzki, D]]
[[Category: Large Structures]]
[[Category: Lehner, F]]
[[Category: Rattus norvegicus]]
[[Category: Schwalbe, H]]
[[Category: Kudlinzki D]]
[[Category: Silvers, R]]
[[Category: Lehner F]]
[[Category: Signaling protein]]
[[Category: Schwalbe H]]
[[Category: Silvers R]]
Retrieved from "https://proteopedia.org/5w72"