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==Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R==
==Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R==
<StructureSection load='5gwi' size='340' side='right' caption='[[5gwi]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
<StructureSection load='5gwi' size='340' side='right'caption='[[5gwi]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5gwi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GWI FirstGlance]. <br>
<table><tr><td colspan='2'>[[5gwi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GWI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N2N:dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3,4 6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum'>N2N</scene>, <scene name='pdbligand=N2R:dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3,4 6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum'>N2R</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.737&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gwj|5gwj]], [[5gwk|5gwk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N2N:N-[(5R,5aS,8aR,9R)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-8-oxidanylidene-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl]-3-[(4R)-2,2-bis(chloranyl)-1$l^{4},3$l^{4}-diaza-2$l^{4}-platinacyclopent-4-yl]propanamide'>N2N</scene>, <scene name='pdbligand=N2R:dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3,4 6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum'>N2R</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TOP2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gwi OCA], [https://pdbe.org/5gwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gwi RCSB], [https://www.ebi.ac.uk/pdbsum/5gwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gwi ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gwi OCA], [http://pdbe.org/5gwi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gwi RCSB], [http://www.ebi.ac.uk/pdbsum/5gwi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gwi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5gwi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5gwi" style="background-color:#fffaf0;"></div>
==See Also==
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chan, N L]]
[[Category: Large Structures]]
[[Category: Chen, S F]]
[[Category: Synthetic construct]]
[[Category: Wang, Y R]]
[[Category: Chan NL]]
[[Category: Wu, C C]]
[[Category: Chen SF]]
[[Category: Anti-cancer drug]]
[[Category: Wang YR]]
[[Category: Isomerase-dna complex]]
[[Category: Wu CC]]
[[Category: Isomerase-dna-isomerase inhibitor complex]]
[[Category: Topoii cleavage complex]]
[[Category: Type ii topoisomerase]]
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