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==PASTA subunit 4 of Streptococcus pneumoniae STKP crystallized with PEG and succinate==
==PASTA subunit 4 of Streptococcus pneumoniae STKP crystallized with PEG and succinate==
<StructureSection load='5nod' size='340' side='right' caption='[[5nod]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5nod' size='340' side='right'caption='[[5nod]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nod]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NOD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">stkP, pkn2, spr1577 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nod OCA], [https://pdbe.org/5nod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nod RCSB], [https://www.ebi.ac.uk/pdbsum/5nod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nod ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nod OCA], [http://pdbe.org/5nod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nod RCSB], [http://www.ebi.ac.uk/pdbsum/5nod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STKP_STRR6 STKP_STRR6]] Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA and StkP itself. Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP (shown in the avirulent strain Rx / Cp1015); PhpP and StkP appear to constitute a functional signaling couple in vivo.<ref>PMID:22211696</ref> <ref>PMID:22431591</ref>
[https://www.uniprot.org/uniprot/STKP_STRR6 STKP_STRR6] Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA and StkP itself. Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP (shown in the avirulent strain Rx / Cp1015); PhpP and StkP appear to constitute a functional signaling couple in vivo.<ref>PMID:22211696</ref> <ref>PMID:22431591</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Strr6]]
[[Category: Streptococcus pneumoniae R6]]
[[Category: GALISSON, F]]
[[Category: Galisson F]]
[[Category: GOUET, P]]
[[Category: Gouet P]]
[[Category: GRANGEASSE, C]]
[[Category: Grangeasse C]]
[[Category: GUEGUEN-CHAIGNON, V]]
[[Category: Gueguen-Chaignon V]]
[[Category: ZUCCHINI, L]]
[[Category: Zucchini L]]
[[Category: Extracellular domain]]
[[Category: Pasta]]
[[Category: Ser/thr kinase]]
[[Category: Streptococcus pneumoniae]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5nod"