1dz5: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein==
==The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein==
<StructureSection load='1dz5' size='340' side='right' caption='[[1dz5]], [[NMR_Ensembles_of_Models | 13 NMR models]]' scene=''>
<StructureSection load='1dz5' size='340' side='right'caption='[[1dz5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1dz5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1dz5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DZ5 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aud|1aud]], [[1fht|1fht]], [[1urn|1urn]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dz5 OCA], [http://pdbe.org/1dz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1dz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dz5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dz5 OCA], [https://pdbe.org/1dz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1dz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dz5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 28: Line 28:
</div>
</div>
<div class="pdbe-citations 1dz5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1dz5" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gunderson, S I]]
[[Category: Large Structures]]
[[Category: Kay, L E]]
[[Category: Gunderson SI]]
[[Category: Mattaj, I W]]
[[Category: Kay LE]]
[[Category: Neuhaus, D]]
[[Category: Mattaj IW]]
[[Category: Varani, G]]
[[Category: Neuhaus D]]
[[Category: Varani, L]]
[[Category: Varani G]]
[[Category: Polyadenylation]]
[[Category: Varani L]]
[[Category: Protein protein interaction]]
[[Category: Ribonucleoprotein-rna complex]]
[[Category: Rna protein interaction]]
Retrieved from "https://proteopedia.org/1dz5"