Albumin: Difference between revisions

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<StructureSection load='' size='350' side='right' scene='Journal:JBSD:26/Cv/7' caption='Human serum albumin (PDB code [[1bm0]])'>
<StructureSection load='' size='350' side='right' scene='Journal:JBSD:26/Cv/7' caption='Human serum albumin (PDB code [[1bm0]])'>
__TOC__
==Function==
'''Albumin''' (Alb) is water-soluble protein.  Serum albumin (SA) is the most abundant blood plasma protein.  SA serves as carrier of fatty acids, bilirubin, ions and drugs.  For details on human serum albumin see<br />
'''Albumin''' (Alb) is water-soluble protein.  Serum albumin (SA) is the most abundant blood plasma protein.  SA serves as carrier of fatty acids, bilirubin, ions and drugs.  For details on human serum albumin see<br />
*[[User:Neeharika Pothuri/Human Serum Albumin]]<br />  
*[[User:Neeharika Pothuri/Human Serum Albumin]]<br />  
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*[[STRUCTURE 1BM0]]<br />
*[[STRUCTURE 1BM0]]<br />
*[[Albumin (Hebrew)]].
*[[Albumin (Hebrew)]].
===  Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>===
==  Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>==
   
   
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
</StructureSection>


== 3D Structures of albumin ==
== 3D Structures of albumin ==
 
[[Albumin 3D structures]]
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Human serum albumin
 
**[[1e78]], [[1bm0]], [[1ao6]], [[1uor]], [[3sqj]], [[4g03]], [[4g04]], [[4k2c]] - hSA – human
 
*Human serum albumin binary complex
 
**[[2ydf]] – hSA + iophenoxic acid<br />
**[[2xvq]], [[2xvu]], [[2xw0]], [[2xw1]] - hSA + dansyl derivative<br />
**[[3lu6]], [[3ju7]], [[3lu8]], [[2bx8]], [[2bxa]], [[2bxb]], [[2bxc]], [[2bxd]], [[2bxe]], [[2bxf ]], [[2bxg]], [[2bxh]], [[2bxi]], [[2bxk]], [[2bxl]], [[2bxm]], [[2bxn]],[[2bxo]], [[2bxp]], [[2bxq]], [[3lu7]], [[4l8u]], [[4l9k]], [[4l9q]], [[4la0]], [[4lb2]], [[4lb9]], [[5ifo]], [[5id9]], [[5id7]] – hSA + drug<br />
**[[4iw1]], [[4iw2]] – hSA + monosaccharide<br />
**[[3jqz]] – hSA + lidocaine<br />
**[[3jry]] - hSA + sulfate<br />
**[[4emx]] – hSA + Cl<br />
**[[5ifj]], [[5ije]], [[5ij5]], [[5iix]], [[5iiu]], [[5iih]] – hSA + Zn<br />
**[[4s1y]] – hSA + cisplatin<br />
**[[1n5u]] - hSA + heme<br />
**[[3a73]] - hSA + prostaglandin<br />
**[[2vuf]], [[2vue]] - hSA + bilirubin derivative<br />
**[[1gni]], [[1gnj]], [[1e7h]], [[1e7e]], [[1e7f]], [[1e7i]], [[1bke]], [[1bj5]], [[3tdl]], [[4e99]], [[4bke]] - hSA + fatty acid<br />
**[[1hk1]] - hSA + thiroxine<br />
**[[2hk2]], [[1hk3]], [[1hk2]] - hSA (mutant) + thiroxine<br />
**[[1e7a]], [[1e7b]] - hSA + general anesthetic<br />
**[[1tf0]] - hSA + peptostreptococcal albumin-binding protein GA module<br />
**[[2esg]] - hSA + immunoglobulin A1<br />
**[[1ysx]] - hSA + anti-apoptotic ligand – NMR<BR />
**[[4hgk]], [[4hgm]], [[5fuo]] – hSA + shark antibody<br />
 
*Human serum albumin ternary complex
 
**[[2xsi]], [[2xvv]], [[2xvw]] – hSA + dansyl derivative + myristic acid<br />
**[[3cx9]] - hSA + lysophospholipid + myristic acid<br />
**[[1e7g]] - hSA + fatty acid + myristic acid<br />
**[[1h9z]], [[1ha2]] - hSA + warfarine + myristic acid<br />
**[[1e7c]] - hSA + general anesthetic + myristic acid<br />
**[[1hk4]] - hSA + thiroxine + myristic acid<br />
**[[1hk5]] - hSA (mutant) + thiroxine + myristic acid<br />
**[[1o9x]] - hSA + hemin + myristic acid<br />
**[[3uiv]] - hSA + amantadine + myristic acid<br />
**[[3b9l]] - hSA + AZT + myristic acid<br />
**[[2i2z]] - hSA + aspirin + myristic acid<br />
**[[2i30]] - hSA + salicylic acid + myristic acid<br />
**[[4z69]] – hSA + palmitate + diclofenac<br />
**[[3b9m]] - hSA + AZT + salicylic acid + myristic acid<br />
**[[2vdb]] - hSA + peptostreptococcal albumin-binding protein GA module + naproxen<br />
**[[4k71]], [[4n0f]] – hSA + Igg receptor + β-2-microglobulin<br />
**[[4n0u]] – hSA + Igg receptor + β-2-microglobulin + Ig γ-1 chain C<br />
 
*Other serum albumins
 
**[[3v03]], [[4f5s]] - bSA – bovine<br />
**[[3v08]], [[4f5t]], [[4f5u]], [[5hoz]] – hoSA – horse<br />
**[[3v09]], [[4f5v]] – rSA – rabbit<br />
**[[4luf]] – sSA – sheep<br />
**[[3vvj]] – SA – emu<br />
**[[5ghk]] – SA – dog<br />
**[[4j2v]] – hoSA + diiodosalicilate<br />
**[[4jk4]] – bSA + diiodosalicilate<br />
**[[4luh]] – sSA + diiodosalicilate<br />
**[[4or0]] – bSA + drug<br />
**[[4ot2]], [[5dqf]], [[5dby]], [[4zbr]], [[4zbq]]  – hoSA + drug<br />
**[[4po0]] – rSA + drug<br />


</StructureSection>


*Albumin


**[[1s6d]] – Alb 8 – sunflower – NMR<BR />
**[[1wba]] – Alb 1 – winged bean<br />
**[[1p8b]] – Alb 1 – pea<br />
**[[1psy]] – Alb – castor bean - NMR<br />
**[[3lp9]] – Alb hemopexin domain – ''Lathyrus sativus''<br />
**[[2lvf]] – Alb – Brazil nut<br />
**[[5dom]] – SA 2S – horseradish tree<br />
}}
'''References'''
'''References'''
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 07:45, 4 March 2019

Human serum albumin (PDB code 1bm0)

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References

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Alexander Berchansky, Michal Harel, Jaime Prilusky

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