6bwd: Difference between revisions
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==3.7 angstrom cryoEM structure of truncated mouse TRPM7== | |||
<SX load='6bwd' size='340' side='right' viewer='molstar' caption='[[6bwd]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bwd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BWD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwd OCA], [https://pdbe.org/6bwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bwd RCSB], [https://www.ebi.ac.uk/pdbsum/6bwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRPM7_MOUSE TRPM7_MOUSE] Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).<ref>PMID:11385574</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Abiria SA]] | |||
[[Category: Clapham DE]] | |||
[[Category: Duan J]] | |||
[[Category: Hulse RE]] | |||
[[Category: Krapivinsky G]] | |||
[[Category: Li J]] | |||
[[Category: Li Z]] | |||
[[Category: Santa-Cruz A]] | |||
[[Category: Zhang J]] | |||