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==Structural Basis for Shelterin Bridge Assembly==
==Structural Basis for Shelterin Bridge Assembly==
<StructureSection load='5we1' size='340' side='right' caption='[[5we1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5we1' size='340' side='right'caption='[[5we1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5we1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WE1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5we1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WE1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.202&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5we1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5we1 OCA], [http://pdbe.org/5we1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5we1 RCSB], [http://www.ebi.ac.uk/pdbsum/5we1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5we1 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5we1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5we1 OCA], [https://pdbe.org/5we1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5we1 RCSB], [https://www.ebi.ac.uk/pdbsum/5we1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5we1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/POZ1_SCHPO POZ1_SCHPO]] Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.<ref>PMID:18535244</ref> [[http://www.uniprot.org/uniprot/TPZ1_SCHPO TPZ1_SCHPO]] Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively.<ref>PMID:16303567</ref> <ref>PMID:18535244</ref> 
[https://www.uniprot.org/uniprot/POZ1_SCHPO POZ1_SCHPO] Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.<ref>PMID:18535244</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hu, X]]
[[Category: Large Structures]]
[[Category: Huang, L]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Kim, J K]]
[[Category: Hu X]]
[[Category: Komives, E A]]
[[Category: Huang L]]
[[Category: Liu, J]]
[[Category: Kim J-K]]
[[Category: Qiao, F]]
[[Category: Komives E-A]]
[[Category: Roskamp, K]]
[[Category: Liu J]]
[[Category: Sankaran, B]]
[[Category: Qiao F]]
[[Category: Yu, C]]
[[Category: Roskamp K]]
[[Category: Cooperativity]]
[[Category: Sankaran B]]
[[Category: Gene regulation]]
[[Category: Yu C]]
[[Category: Shelterin]]
[[Category: Telomere]]
Retrieved from "https://proteopedia.org/5we1"