Merlin: Difference between revisions

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== Function ==

'''Merlin''' (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.

'''Merlin''' (Mer) or '''Moesin-exrin-radixin-like protein''' is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.

== Disease ==

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[3u8z]], [[1h4r]] – hMer ~~FERM domain~~ – human

'''Merlin FERM domain 1-320'''

[[4zrj]] – hMer ~~FERM~~ + C-terminal domain (mutant)

[[1isn]] – mMer ~~FERM domain~~ - mouse

[[3u8z]], [[1h4r]] – hMer – human

[[3wa0]] – mMer ~~FERM domain~~ + HIV-1 Vpr-binding protein residues 1417-1506

[[6cds]] – hMer (mutant)

[[4p7i]] – mMer ~~FERM domain~~ + HIV-1 Vpr-binding protein residues 998-1058

[[4zrj]] – hMer + C-terminal domain (mutant)

[[4zrk]] – mMer ~~FERM domain~~ + Lats1 peptide

[[7lwh]] – hMer + Lats1 peptide

[[~~4zri~~]] – ~~hMer FERM~~ domain ~~+ Lats2 peptide~~

[[4zri]] – hMer + Lats2 peptide

[[1isn]] – mMer - mouse

[[3wa0]] – mMer + HIV-1 Vpr-binding protein residues 1417-1506

[[4p7i]] – mMer + HIV-1 Vpr-binding protein residues 998-1058

[[4zrk]] – mMer + Lats1 peptide

[[7edr]] – Mer + C-terminal domain 510-635 – ''Drosophila melanogaster''

== References ==

[[Category:Topic Page]]

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@@ Line 1: / Line 1: @@
-<StructureSection load='' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>
+<StructureSection load='3wa0' size='340' side='right' caption='Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code [[3wa0]])' scene=''>
 == Function ==
-'''Merlin''' (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>.  The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.
+'''Merlin''' (Mer) or '''Moesin-exrin-radixin-like protein''' is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface<ref>PMID:21167305</ref>.  The FERM domain of Mer regulates cell proliferation in response to adhesive signaling<ref>PMID:24726726</ref>.
 == Disease ==
@@ Line 18: / Line 18: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[3u8z]], [[1h4r]] – hMer FERM domain – human  <br />
+'''Merlin FERM domain 1-320'''
-[[4zrj]] – hMer FERM + C-terminal domain  (mutant) <br />
-[[1isn]] – mMer FERM domain - mouse<br />
+[[3u8z]], [[1h4r]] – hMer – human  <br />
-[[3wa0]] – mMer FERM domain + HIV-1 Vpr-binding protein residues 1417-1506 <br />
+[[6cds]] – hMer (mutant) <br />
-[[4p7i]] – mMer FERM domain + HIV-1 Vpr-binding protein residues 998-1058 <br />
+[[4zrj]] – hMer + C-terminal domain  (mutant) <br />
-[[4zrk]] – mMer FERM domain + Lats1 peptide <br />
+[[7lwh]] – hMer + Lats1 peptide <br />
-[[4zri]] – hMer FERM domain + Lats2 peptide <br />
+[[4zri]] – hMer + Lats2 peptide <br />
+[[1isn]] – mMer - mouse<br />
+[[3wa0]] – mMer + HIV-1 Vpr-binding protein residues 1417-1506 <br />
+[[4p7i]] – mMer + HIV-1 Vpr-binding protein residues 998-1058 <br />
+[[4zrk]] – mMer + Lats1 peptide <br />
+[[7edr]] – Mer + C-terminal domain  510-635 – ''Drosophila melanogaster'' <br />
 == References ==
 <references/>
 [[Category:Topic Page]]