5z0v: Difference between revisions

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'''Unreleased structure'''


The entry 5z0v is ON HOLD
==Structural insight into the Zika virus capsid encapsulating the viral genome==
<StructureSection load='5z0v' size='340' side='right'caption='[[5z0v]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5z0v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z0V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.913&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z0v OCA], [https://pdbe.org/5z0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z0v RCSB], [https://www.ebi.ac.uk/pdbsum/5z0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z0v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763]  prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763]  Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763]  Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763]  Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732]  Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763]  Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763]  Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]


Authors: Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., Zhang, T., Duan, Y., Xue, X., Mi, K., Ji, X., Wang, Z., Yang, H.
==See Also==
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
Description: Structural insight into the Zika virus capsid encapsulating the viral genome
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Yang, X]]
[[Category: Large Structures]]
[[Category: Mi, K]]
[[Category: Zika virus]]
[[Category: Xue, X]]
[[Category: Chen C]]
[[Category: Yang, H]]
[[Category: Duan Y]]
[[Category: Zhang, T]]
[[Category: Ji X]]
[[Category: Wu, C]]
[[Category: Li T]]
[[Category: Ji, X]]
[[Category: Mi K]]
[[Category: Li, T]]
[[Category: Wang Z]]
[[Category: Wang, Z]]
[[Category: Wu C]]
[[Category: Duan, Y]]
[[Category: Xue X]]
[[Category: Yang, K]]
[[Category: Yang H]]
[[Category: Chen, C]]
[[Category: Yang K]]
[[Category: Zhao, Q]]
[[Category: Yang X]]
[[Category: Zhang T]]
[[Category: Zhao Q]]
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