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==Structure of TNRC6A NLS in complex with importin-alpha==
==Structure of TNRC6A NLS in complex with importin-alpha==
<StructureSection load='5umz' size='340' side='right' caption='[[5umz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5umz' size='340' side='right'caption='[[5umz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5umz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UMZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5umz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UMZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5umz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umz OCA], [http://pdbe.org/5umz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umz RCSB], [http://www.ebi.ac.uk/pdbsum/5umz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umz ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5umz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umz OCA], [https://pdbe.org/5umz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5umz RCSB], [https://www.ebi.ac.uk/pdbsum/5umz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5umz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5umz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5umz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chaston, J]]
[[Category: Large Structures]]
[[Category: Christie, M]]
[[Category: Mus musculus]]
[[Category: Stewart, A G]]
[[Category: Chaston J]]
[[Category: Mirna arm repeat]]
[[Category: Christie M]]
[[Category: Mrna decay]]
[[Category: Stewart AG]]
[[Category: Nuclear transport]]
[[Category: Protein transport]]
Retrieved from "https://proteopedia.org/5umz"