2cr4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2cr4.gif|left|200px]]


{{Structure
==Solution structure of the SH2 domain of human SH3BP2 protein==
|PDB= 2cr4 |SIZE=350|CAPTION= <scene name='initialview01'>2cr4</scene>
<StructureSection load='2cr4' size='340' side='right'caption='[[2cr4]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [https://pdbe.org/2cr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Disease ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB]</span>
[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[https://omim.org/entry/118400 118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>
}}
== Function ==
 
[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
'''Solution structure of the SH2 domain of human SH3BP2 protein'''
== References ==
 
<references/>
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Cherubism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602104 602104]]
 
==About this Structure==
2CR4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].  
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hatta, R.]]
[[Category: Hatta R]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: 3bp-2]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: sh2 domain]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:25:20 2008''
Retrieved from "https://proteopedia.org/2cr4"