2cr7: Difference between revisions

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[[Image:2cr7.gif|left|200px]]


{{Structure
==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B==
|PDB= 2cr7 |SIZE=350|CAPTION= <scene name='initialview01'>2cr7</scene>
<StructureSection load='2cr7' size='340' side='right'caption='[[2cr7]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR7 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= SIN3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [https://pdbe.org/2cr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr7 TOPSAN]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [http://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB]</span>
[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cr7_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2CR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cr7 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Hayashi F]]
[[Category: Hayashi, F.]]
[[Category: Nagashima K]]
[[Category: Nagashima, K.]]
[[Category: Yokoyama S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yoshida M]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida, M.]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: paired amphipathic helix repeat]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transcriptional repressor]]
 
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Retrieved from "https://proteopedia.org/2cr7"