6bzg: Difference between revisions

Latest revision as of 14:25, 13 March 2024

Structure of S. cerevisiae Zip2:Spo16 complex, P212121 form

Structural highlights

6bzg is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.13Å
Ligands:	P6G, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZIP2_YEAST Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ San-Segundo PA, Roeder GS. Pch2 links chromatin silencing to meiotic checkpoint control. Cell. 1999 Apr 30;97(3):313-24. PMID:10319812
↑ Bailis JM, Smith AV, Roeder GS. Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol. 2000 Jul;20(13):4838-48. PMID:10848609
↑ Agarwal S, Roeder GS. Zip3 provides a link between recombination enzymes and synaptonemal complex proteins. Cell. 2000 Jul 21;102(2):245-55. PMID:10943844
↑ Novak JE, Ross-Macdonald PB, Roeder GS. The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics. 2001 Jul;158(3):1013-25. PMID:11454751
↑ Peoples-Holst TL, Burgess SM. Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast. Genes Dev. 2005 Apr 1;19(7):863-74. doi: 10.1101/gad.1293605. PMID:15805472 doi:https://dx.doi.org/10.1101/gad.1293605
↑ Tsubouchi T, Zhao H, Roeder GS. The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2. Dev Cell. 2006 Jun;10(6):809-19. doi: 10.1016/j.devcel.2006.04.003. PMID:16740482 doi:https://dx.doi.org/10.1016/j.devcel.2006.04.003
↑ Chua PR, Roeder GS. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell. 1998 May 1;93(3):349-59. PMID:9590170

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] San-Segundo PA, Roeder GS. Pch2 links chromatin silencing to meiotic checkpoint control. Cell. 1999 Apr 30;97(3):313-24. PMID:10319812

[2] Bailis JM, Smith AV, Roeder GS. Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol. 2000 Jul;20(13):4838-48. PMID:10848609

[3] Agarwal S, Roeder GS. Zip3 provides a link between recombination enzymes and synaptonemal complex proteins. Cell. 2000 Jul 21;102(2):245-55. PMID:10943844

[4] Novak JE, Ross-Macdonald PB, Roeder GS. The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics. 2001 Jul;158(3):1013-25. PMID:11454751

[5] Peoples-Holst TL, Burgess SM. Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast. Genes Dev. 2005 Apr 1;19(7):863-74. doi: 10.1101/gad.1293605. PMID:15805472 doi:https://dx.doi.org/10.1101/gad.1293605

[6] Tsubouchi T, Zhao H, Roeder GS. The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2. Dev Cell. 2006 Jun;10(6):809-19. doi: 10.1016/j.devcel.2006.04.003. PMID:16740482 doi:https://dx.doi.org/10.1016/j.devcel.2006.04.003

[7] Chua PR, Roeder GS. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell. 1998 May 1;93(3):349-59. PMID:9590170

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bzg is ON HOLD
+==Structure of S. cerevisiae Zip2:Spo16 complex, P212121 form==
+<StructureSection load='6bzg' size='340' side='right'caption='[[6bzg]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-Authors: Arora, K., Corbett, K.D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bzg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZG FirstGlance]. <br>
-Description: Structure of S. cerevisiae Zip2:Spo16 complex, P212121 form
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Corbett, K.D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzg OCA], [https://pdbe.org/6bzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bzg RCSB], [https://www.ebi.ac.uk/pdbsum/6bzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzg ProSAT]</span></td></tr>
-[[Category: Arora, K]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ZIP2_YEAST ZIP2_YEAST] Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes.<ref>PMID:10319812</ref> <ref>PMID:10848609</ref> <ref>PMID:10943844</ref> <ref>PMID:11454751</ref> <ref>PMID:15805472</ref> <ref>PMID:16740482</ref> <ref>PMID:9590170</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Arora K]]
+[[Category: Corbett KD]]

6bzg: Difference between revisions

Latest revision as of 14:25, 13 March 2024

Structure of S. cerevisiae Zip2:Spo16 complex, P212121 form

Structural highlights

Function

References

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