5w9s: Difference between revisions

<StructureSection load='5w9s' size='340' side='right'caption='[[5w9s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[5w9s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W9S FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w9s OCA], [https://pdbe.org/5w9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w9s RCSB], [https://www.ebi.ac.uk/pdbsum/5w9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w9s ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CXXC5_HUMAN CXXC5_HUMAN] May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).<ref>PMID:19182210</ref> <ref>PMID:19557330</ref> <ref>PMID:23303788</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Synthetic construct]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Edwards AM]]

[[Category: Liu K]]

[[Category: Min J]]

[[Category: Tempel W]]

[[Category: Walker JR]]

[[Category: Xu C]]