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==DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS==
==DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS==
<StructureSection load='1gg8' size='340' side='right' caption='[[1gg8]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='1gg8' size='340' side='right'caption='[[1gg8]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GG8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GG8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLG:ALPHA-D-GLUCOPYRANOSYL-2-CARBOXYLIC+ACID+AMIDE'>GLG</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLG:ALPHA-D-GLUCOPYRANOSYL-2-CARBOXYLIC+ACID+AMIDE'>GLG</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg8 OCA], [http://pdbe.org/1gg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1gg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gg8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg8 OCA], [https://pdbe.org/1gg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1gg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.  
[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1gg8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1gg8" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Bichard CJ]]
[[Category: Bichard, C J]]
[[Category: Fleet GW]]
[[Category: Fleet, G W]]
[[Category: Johnson LN]]
[[Category: Johnson, L N]]
[[Category: Kontou M]]
[[Category: Kontou, M]]
[[Category: Leonidas DD]]
[[Category: Leonidas, D D]]
[[Category: Mitchell EP]]
[[Category: Mitchell, E P]]
[[Category: Oikonomakos NG]]
[[Category: Oikonomakos, N G]]
[[Category: Orchard MG]]
[[Category: Orchard, M G]]
[[Category: Papageorgiou AC]]
[[Category: Papageorgiou, A C]]
[[Category: Son JC]]
[[Category: Son, J C]]
[[Category: Watson KA]]
[[Category: Watson, K A]]
[[Category: Catalytic site]]
[[Category: Design]]
[[Category: Glycogen phosphorylase]]
[[Category: Inhibitor complex]]
[[Category: Transferase]]
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