Glycoprotein GP: Difference between revisions

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<StructureSection load='3s88' size='340' side='right' caption='Ebolavirus GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code [[3s88]])' scene=''>
<StructureSection load='3s88' size='340' side='right' caption='Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code [[3s88]])' scene=''>




== Function ==
== Function ==


The virus contains a surface '''glycoprotein PG''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.
The virus contains a surface '''glycoprotein GP''' or '''envelope glycoprotein GP''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.


For details see [[GP1 of Lassa Virus]].
For details see [[GP1 of Lassa Virus]].


== Disease ==
== 3D Structures of glycoprotein GP ==
 
[[Glycoprotein GP 3D structures]]
== Relevance ==
 
== Structural highlights ==


</StructureSection>
</StructureSection>


== 3D Structures of glycoprotein GP ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Glycoprotein GP
**[[2wfo]] – MvGP1 – Machupo virus <br />
**[[4zjf]] – GP1 – Lassa virus <br />
**[[5nff]] – GP1 – Morogoro virus <br />
**[[5nsj]] – GP1 – Whitewater arroyo mammarenavirus <br />
**[[3lj5]], [[4v4k]] – GP1 – Bacteriophage p22 <br />
**Glycoprotein GP complex
**[[3ve0]], [[3s88]] – GP1 + GP2 + antibody – Sudan ebolavirus <br />
**[[5f1b]] – ZevGP1 + GP2 + Niemann-Pick C1 protein – Zaire ebolavirus <br />
**[[6f5u]], [[6f6i]], [[6f6n]], [[6f6s]] – ZevGP1 + GP2 + antidepressant <br />
**[[3csy]], [[5kel]], [[5ken]] – ZevGP1 + GP2 + antibody <br />
**[[5uqy]] – GP1 + GP2 + antibody – Marburg virus <br />
**[[3kas]] – MvGP1 + transferrin receptor 1 <br />
**[[5nuz]] – GP1 + antibody – Junin virus <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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