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==CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE==
==CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE==
<StructureSection load='1hq3' size='340' side='right' caption='[[1hq3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='1hq3' size='340' side='right'caption='[[1hq3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1hq3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HQ3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1hq3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQ3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq3 OCA], [http://pdbe.org/1hq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hq3 RCSB], [http://www.ebi.ac.uk/pdbsum/1hq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq3 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq3 OCA], [https://pdbe.org/1hq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1hq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H4_CHICK H4_CHICK]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_CHICK H32_CHICK]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  
[https://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1hq3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1hq3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Baldwin, J P]]
[[Category: Large Structures]]
[[Category: Chantalat, L]]
[[Category: Baldwin JP]]
[[Category: Donovan, M J]]
[[Category: Chantalat L]]
[[Category: Lambert, S J]]
[[Category: Donovan MJ]]
[[Category: Nicholson, J M]]
[[Category: Lambert SJ]]
[[Category: Reid, A J]]
[[Category: Nicholson JM]]
[[Category: Reynolds, C D]]
[[Category: Reid AJ]]
[[Category: Wood, C M]]
[[Category: Reynolds CD]]
[[Category: Chromatin]]
[[Category: Wood CM]]
[[Category: Cl and phosphate ion]]
[[Category: Dna binding protein]]
[[Category: Histone-core octamer]]
[[Category: Histone-tail guide helice]]
[[Category: Nucleosome]]
[[Category: Structural element]]
[[Category: Tether structure]]
[[Category: Water]]
Retrieved from "https://proteopedia.org/1hq3"