2c4e: Difference between revisions
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==Crystal Structure of Methanocaldococcus jannaschii Nucleoside Kinase - An Archaeal Member of the Ribokinase Family== | ==Crystal Structure of Methanocaldococcus jannaschii Nucleoside Kinase - An Archaeal Member of the Ribokinase Family== | ||
<StructureSection load='2c4e' size='340' side='right' caption='[[2c4e]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2c4e' size='340' side='right'caption='[[2c4e]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c4e]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2c4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4E FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4e OCA], [https://pdbe.org/2c4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4e RCSB], [https://www.ebi.ac.uk/pdbsum/2c4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NK_METJA NK_METJA] Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate.<ref>PMID:17021658</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arnfors | [[Category: Methanocaldococcus jannaschii]] | ||
[[Category: Hansen | [[Category: Arnfors L]] | ||
[[Category: Ladenstein | [[Category: Hansen T]] | ||
[[Category: Meining | [[Category: Ladenstein R]] | ||
[[Category: Schoenheit | [[Category: Meining W]] | ||
[[Category: Schoenheit P]] | |||
