2dde: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2dde.gif|left|200px]]


{{Structure
==Structure of cinnamycin complexed with lysophosphatidylethanolamine==
|PDB= 2dde |SIZE=350|CAPTION= <scene name='initialview01'>2dde</scene>
<StructureSection load='2dde' size='340' side='right'caption='[[2dde]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BHD:BETA-HYDROXYASPARTIC+ACID'>BHD</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=LSP:(7S)-4,7-DIHYDROXY-10-OXO-3,5,9-TRIOXA-4-PHOSPHAUNDECAN-1-AMINIUM+4-OXIDE'>LSP</scene>
<table><tr><td colspan='2'>[[2dde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDE FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BH2:(3R)-3-HYDROXY-L-ASPARTIC+ACID'>BH2</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=LSP:(7S)-4,7-DIHYDROXY-10-OXO-3,5,9-TRIOXA-4-PHOSPHAUNDECAN-1-AMINIUM+4-OXIDE'>LSP</scene>, <scene name='pdbligand=PRD_000195:Cinnamycin'>PRD_000195</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dde OCA], [https://pdbe.org/2dde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dde RCSB], [https://www.ebi.ac.uk/pdbsum/2dde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dde ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dde OCA], [http://www.ebi.ac.uk/pdbsum/2dde PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dde RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CINA_STRGV CINA_STRGV] Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced.
 
<div style="background-color:#fffaf0;">
'''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''
== Publication Abstract from PubMed ==
 
 
==Overview==
The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.
The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.


==About this Structure==
Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1.,Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K J Biochem. 1996 Feb;119(2):226-30. PMID:8882709<ref>PMID:8882709</ref>
2DDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8882709 8882709]
</div>
[[Category: Single protein]]
<div class="pdbe-citations 2dde" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces griseoverticillatus]]
[[Category: Streptomyces griseoverticillatus]]
[[Category: Endo, S.]]
[[Category: Endo S]]
[[Category: Hosoda, K.]]
[[Category: Hosoda K]]
[[Category: Kohno, T.]]
[[Category: Kohno T]]
[[Category: Maeda, T.]]
[[Category: Maeda T]]
[[Category: Ohya, M.]]
[[Category: Ohya M]]
[[Category: Wakamatsu, K.]]
[[Category: Wakamatsu K]]
[[Category: immunopotentiator]]
[[Category: lanthionine]]
[[Category: lipid binding]]
[[Category: phosphatidylethanolamine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:33:11 2008''
Retrieved from "https://proteopedia.org/2dde"