2ddj: Difference between revisions

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[[Image:2ddj.jpg|left|200px]]


{{Structure
==NMR structure of the second Kunitz domain of human WFIKKN1==
|PDB= 2ddj |SIZE=350|CAPTION= <scene name='initialview01'>2ddj</scene>
<StructureSection load='2ddj' size='340' side='right'caption='[[2ddj]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2ddj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDJ FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
|GENE= WFIKKN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ddj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddj OCA], [https://pdbe.org/2ddj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ddj RCSB], [https://www.ebi.ac.uk/pdbsum/2ddj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ddj ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[2ddi|2DDI]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddj OCA], [http://www.ebi.ac.uk/pdbsum/2ddj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ddj RCSB]</span>
[https://www.uniprot.org/uniprot/WFKN1_HUMAN WFKN1_HUMAN] Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''NMR structure of the second Kunitz domain of human WFIKKN1'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/2ddj_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
2DDJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDJ OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ddj ConSurf].
Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein., Liepinsh E, Nagy A, Trexler M, Patthy L, Otting G, J Biomol NMR. 2006 May;35(1):73-8. Epub 2006 Jun 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16791741 16791741]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Liepinsh, E.]]
[[Category: Liepinsh E]]
[[Category: Otting, G.]]
[[Category: Otting G]]
[[Category: kunitz domain]]
 
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Retrieved from "https://proteopedia.org/2ddj"