4d1g

Crystal structure of the fiber head domain of the Atadenovirus snake adenovirus 1, native, second P212121 crystal form

spinqualitylabelsall models 4d1g, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4d1g is a 12 chain structure with sequence from Snake adenovirus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.9Å Ligands: PE8, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SPIKE_ADES1 Publication Abstract from PubMed Adenoviruses are non-enveloped icosahedral viruses with trimeric fibre proteins protruding from their vertices. There are five known genera, from which only Mastadenoviruses have been widely studied. Apart from studying adenovirus as a biological model system and with a view to prevent or combat viral infection, there is a major interest in using adenovirus for vaccination, cancer therapy and gene therapy purposes. Adenoviruses from the Atadenovirus genus have been isolated from squamate reptile hosts, ruminants and birds and have a characteristic gene organization and capsid morphology. The carboxy-terminal virus-distal fibre head domains are likely responsible for primary receptor recognition. We determined the high-resolution crystal structure of the Snake Adenovirus 1 (SnAdV-1) fibre head using the multi-wavelength anomalous dispersion (MAD) method. Despite the absence of significant sequence homology, this Atadenovirus fibre head has the same beta-sandwich propeller topology as other adenovirus fibre heads. However, it is about half the size, mainly due to much shorter loops connecting the beta-strands. The detailed structure of the SnAdV-1 fibre head and other animal adenovirus fibre heads, together with the future identification of their natural receptors, may lead to the development of new strategies to target adenovirus vectors to cells of interest. Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1.,Singh AK, Menendez-Conejero R, San Martin C, van Raaij MJ PLoS One. 2014 Dec 8;9(12):e114373. doi: 10.1371/journal.pone.0114373., eCollection 2014. PMID:25486282 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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