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==The crystal structure of the OAS-like domain (OLD) of human OASL==
==The crystal structure of the OAS-like domain (OLD) of human OASL==
<StructureSection load='4xq7' size='340' side='right' caption='[[4xq7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4xq7' size='340' side='right'caption='[[4xq7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xq7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQ7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQ7 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OASL, TRIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xq7 OCA], [http://pdbe.org/4xq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xq7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xq7 OCA], [https://pdbe.org/4xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/4xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xq7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OASL_HUMAN OASL_HUMAN]] Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.<ref>PMID:9826176</ref> <ref>PMID:18931074</ref> <ref>PMID:20074559</ref>
[https://www.uniprot.org/uniprot/OASL_HUMAN OASL_HUMAN] Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.<ref>PMID:9826176</ref> <ref>PMID:18931074</ref> <ref>PMID:20074559</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Andersen, L L]]
[[Category: Large Structures]]
[[Category: Gad, H H]]
[[Category: Andersen LL]]
[[Category: Hartmann, R]]
[[Category: Gad HH]]
[[Category: Hornung, V]]
[[Category: Hartmann R]]
[[Category: Ibsen, M S]]
[[Category: Hornung V]]
[[Category: Julkunen, I]]
[[Category: Ibsen MS]]
[[Category: Sarkar, S N]]
[[Category: Julkunen I]]
[[Category: 2'-5' oligoadenylate synthetase]]
[[Category: Sarkar SN]]
[[Category: Oa]]
[[Category: Oasl]]
[[Category: Oligoadenylate synthetase]]
[[Category: Oligoadenylate synthetase-like]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4xq7"