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==Structure of plasmepsin II from Plasmodium falciparum complexed with inhibitor PG418==
==Structure of plasmepsin II from Plasmodium falciparum complexed with inhibitor PG418==
<StructureSection load='4y6m' size='340' side='right' caption='[[4y6m]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
<StructureSection load='4y6m' size='340' side='right'caption='[[4y6m]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4y6m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y6M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4y6m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y6M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48Q:~{N}1-[(~{Z},3~{R})-4-[2-(3-METHOXYPHENYL)PROPAN-2-YLAMINO]-3-OXIDANYL-1-PHENYL-BUT-1-EN-2-YL]-5-PIPERIDIN-1-YL-~{N}3,~{N}3-DIPROPYL-BENZENE-1,3-DICARBOXAMIDE'>48Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cku|4cku]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48Q:~{N}1-[(~{Z},3~{R})-4-[2-(3-METHOXYPHENYL)PROPAN-2-YLAMINO]-3-OXIDANYL-1-PHENYL-BUT-1-EN-2-YL]-5-PIPERIDIN-1-YL-~{N}3,~{N}3-DIPROPYL-BENZENE-1,3-DICARBOXAMIDE'>48Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6m OCA], [https://pdbe.org/4y6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y6m RCSB], [https://www.ebi.ac.uk/pdbsum/4y6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6m OCA], [http://pdbe.org/4y6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y6m RCSB], [http://www.ebi.ac.uk/pdbsum/4y6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4y6m" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4y6m" style="background-color:#fffaf0;"></div>
==See Also==
*[[Plasmepsin|Plasmepsin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plafa]]
[[Category: Large Structures]]
[[Category: Plasmepsin II]]
[[Category: Plasmodium falciparum]]
[[Category: Akopjana, I]]
[[Category: Akopjana I]]
[[Category: Jaudzems, K]]
[[Category: Jaudzems K]]
[[Category: Recacha, R]]
[[Category: Recacha R]]
[[Category: Tars, K]]
[[Category: Tars K]]
[[Category: Hydrolase]]
[[Category: Plasmepsin ii hydroxyethylamine-basd inhibitor]]
Retrieved from "https://proteopedia.org/4y6m"