6aqf: Difference between revisions
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==Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris== | ==Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris== | ||
<StructureSection load='6aqf' size='340' side='right' caption='[[6aqf]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='6aqf' size='340' side='right'caption='[[6aqf]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6aqf]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6aqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AQF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqf OCA], [https://pdbe.org/6aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aqf RCSB], [https://www.ebi.ac.uk/pdbsum/6aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6aqf" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6aqf" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Audet | [[Category: Homo sapiens]] | ||
[[Category: Didenko | [[Category: Large Structures]] | ||
[[Category: Eddy | [[Category: Audet M]] | ||
[[Category: Gao | [[Category: Didenko T]] | ||
[[Category: Han | [[Category: Eddy MT]] | ||
[[Category: Horst | [[Category: Gao Z]] | ||
[[Category: Jacobson | [[Category: Han GW]] | ||
[[Category: Lee | [[Category: Horst R]] | ||
[[Category: McClary | [[Category: Jacobson KA]] | ||
[[Category: Stanczak | [[Category: Lee MY]] | ||
[[Category: Stevens | [[Category: McClary KM]] | ||
[[Category: White | [[Category: Stanczak P]] | ||
[[Category: Wuthrich | [[Category: Stevens RC]] | ||
[[Category: White K]] | |||
[[Category: Wuthrich K]] | |||
Latest revision as of 14:22, 4 October 2023
Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris
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