6c4l: Difference between revisions
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New page: '''Unreleased structure''' The entry 6c4l is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures |
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==Yersinopine dehydrogenase (YpODH) - Apo== | |||
<StructureSection load='6c4l' size='340' side='right'caption='[[6c4l]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C4L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4l OCA], [https://pdbe.org/6c4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c4l RCSB], [https://www.ebi.ac.uk/pdbsum/6c4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4l ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ODH_YERPE ODH_YERPE] Catalyzes the NADPH-dependent reductive condensation of pyruvate to the intermediate formed by the adjacently encoded enzyme y2836, namely (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, leading to the production of yersinopine. This is the last step in the biosynthesis of the metallophore yersinopine, which is involved in metal acquisition and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Yersinia virulence. Cannot use alpha-ketoglutarate in place of pyruvate, and displays only poor efficiency with oxaloacetate and glyoxylate.<ref>PMID:29618515</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Yersinia pestis]] | |||
[[Category: Davis CL]] | |||
[[Category: Lamb AL]] | |||
[[Category: McFarlane JS]] | |||
Latest revision as of 14:26, 13 March 2024
Yersinopine dehydrogenase (YpODH) - Apo
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