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==Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium==
==Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium==
<StructureSection load='5wzo' size='340' side='right' caption='[[5wzo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5wzo' size='340' side='right'caption='[[5wzo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wzo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WZO FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wzo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WZO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wzw|5wzw]], [[5wzm|5wzm]], [[5wzs|5wzs]], [[5wzt|5wzt]], [[5wzu|5wzu]], [[5wzv|5wzv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzo OCA], [https://pdbe.org/5wzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wzo RCSB], [https://www.ebi.ac.uk/pdbsum/5wzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzo OCA], [http://pdbe.org/5wzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wzo RCSB], [http://www.ebi.ac.uk/pdbsum/5wzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA2GE_HUMAN PA2GE_HUMAN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.  
[https://www.uniprot.org/uniprot/PA2GE_HUMAN PA2GE_HUMAN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wzo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wzo" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hou, S]]
[[Category: Homo sapiens]]
[[Category: Liu, J]]
[[Category: Large Structures]]
[[Category: Xu, J]]
[[Category: Hou S]]
[[Category: Xu, T]]
[[Category: Liu J]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Xu J]]
[[Category: Inhibitor]]
[[Category: Xu T]]
Retrieved from "https://proteopedia.org/5wzo"