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==Crystal structure of human secreted phospholipase A2 group IIE with Compound 24==
==Crystal structure of human secreted phospholipase A2 group IIE with Compound 24==
<StructureSection load='5wzu' size='340' side='right' caption='[[5wzu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5wzu' size='340' side='right'caption='[[5wzu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wzu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WZU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wzu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WZU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7W3:2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic+acid'>7W3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wzw|5wzw]], [[5wzv|5wzv]], [[5wzt|5wzt]], [[5wzs|5wzs]], [[5wzo|5wzo]], [[5wzm|5wzm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7W3:2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic+acid'>7W3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzu OCA], [https://pdbe.org/5wzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wzu RCSB], [https://www.ebi.ac.uk/pdbsum/5wzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzu OCA], [http://pdbe.org/5wzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wzu RCSB], [http://www.ebi.ac.uk/pdbsum/5wzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA2GE_HUMAN PA2GE_HUMAN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.  
[https://www.uniprot.org/uniprot/PA2GE_HUMAN PA2GE_HUMAN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wzu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wzu" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hou, S]]
[[Category: Homo sapiens]]
[[Category: Liu, J]]
[[Category: Large Structures]]
[[Category: Xu, J]]
[[Category: Hou S]]
[[Category: Xu, T]]
[[Category: Liu J]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Xu J]]
[[Category: Phospholipase a2]]
[[Category: Xu T]]
Retrieved from "https://proteopedia.org/5wzu"