2do0: Difference between revisions

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[[Image:2do0.jpg|left|200px]]


{{Structure
==Solution structure of the RNA binding domain of heterogeneous nuclear ribonucleoprotein M==
|PDB= 2do0 |SIZE=350|CAPTION= <scene name='initialview01'>2do0</scene>
<StructureSection load='2do0' size='340' side='right'caption='[[2do0]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2do0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DO0 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2do0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2do0 OCA], [https://pdbe.org/2do0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2do0 RCSB], [https://www.ebi.ac.uk/pdbsum/2do0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2do0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2do0 TOPSAN]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2do0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2do0 OCA], [http://www.ebi.ac.uk/pdbsum/2do0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2do0 RCSB]</span>
[https://www.uniprot.org/uniprot/HNRPM_HUMAN HNRPM_HUMAN] Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2do0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2do0 ConSurf].
<div style="clear:both"></div>


'''Solution structure of the RNA binding domain of heterogeneous nuclear ribonucleoprotein M'''
==See Also==
 
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DO0 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Suzuki S]]
[[Category: Suzuki, S.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: rbd]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rna binding domain]]
[[Category: rna recognition motif]]
[[Category: rnp]]
[[Category: rrm]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:11 2008''
Retrieved from "https://proteopedia.org/2do0"