2x4d: Difference between revisions
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==Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP== | ==Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP== | ||
<StructureSection load='2x4d' size='340' side='right' caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | <StructureSection load='2x4d' size='340' side='right'caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4D FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4d OCA], [https://pdbe.org/2x4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4d RCSB], [https://www.ebi.ac.uk/pdbsum/2x4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4d ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LHPP_HUMAN LHPP_HUMAN] Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Allerston C]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Gileadi | [[Category: Gileadi C]] | ||
[[Category: Guo | [[Category: Guo K]] | ||
[[Category: Kavanagh | [[Category: Kavanagh KL]] | ||
[[Category: Muniz | [[Category: Muniz JRC]] | ||
[[Category: Oppermann | [[Category: Oppermann U]] | ||
[[Category: Savitsky | [[Category: Savitsky P]] | ||
[[Category: Vollmar | [[Category: Vollmar M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Yue | [[Category: Yue W]] | ||
[[Category: | [[Category: Von Delft F]] | ||
