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==Beta-Scorpion Toxin folded in the periplasm of E.coli==
==Beta-Scorpion Toxin folded in the periplasm of E.coli==
<StructureSection load='4kyp' size='340' side='right' caption='[[4kyp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4kyp' size='340' side='right'caption='[[4kyp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kyp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_scorpion Black scorpion]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KYP FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kyp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hottentotta_judaicus Hottentotta judaicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KYP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bcg|1bcg]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XTRIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6863 Black scorpion])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kyp OCA], [https://pdbe.org/4kyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kyp RCSB], [https://www.ebi.ac.uk/pdbsum/4kyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kyp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kyp OCA], [http://pdbe.org/4kyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kyp RCSB], [http://www.ebi.ac.uk/pdbsum/4kyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kyp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SIXE_HOTJU SIXE_HOTJU]] Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Black scorpion]]
[[Category: Hottentotta judaicus]]
[[Category: Cole, A R]]
[[Category: Large Structures]]
[[Category: Lampert, A]]
[[Category: Cole AR]]
[[Category: Lopes, J L]]
[[Category: Lampert A]]
[[Category: Reilly, A O.O]]
[[Category: Lopes JL]]
[[Category: Wallace, B A]]
[[Category: O'Reilly AO]]
[[Category: Alpha-beta]]
[[Category: Wallace BA]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Voltage gated na-channel]]
Retrieved from "https://proteopedia.org/4kyp"