4lts: Difference between revisions
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==Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors== | ==Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors== | ||
<StructureSection load='4lts' size='340' side='right' caption='[[4lts]], [[Resolution|resolution]] 1.69Å' scene=''> | <StructureSection load='4lts' size='340' side='right'caption='[[4lts]], [[Resolution|resolution]] 1.69Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lts]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lts]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LTS FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LTS:2-CYANO-1-PYRIDIN-4-YL-3-(4-{[3-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}BENZYL)GUANIDINE'>LTS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.692Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LTS:2-CYANO-1-PYRIDIN-4-YL-3-(4-{[3-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}BENZYL)GUANIDINE'>LTS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lts OCA], [https://pdbe.org/4lts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lts RCSB], [https://www.ebi.ac.uk/pdbsum/4lts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lts ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 4lts" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4lts" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bair | [[Category: Bair KW]] | ||
[[Category: Baumeister | [[Category: Baumeister T]] | ||
[[Category: Buckmelter | [[Category: Buckmelter AJ]] | ||
[[Category: Caligiuri | [[Category: Caligiuri M]] | ||
[[Category: Clodfelter | [[Category: Clodfelter KH]] | ||
[[Category: Dragovich | [[Category: Dragovich PS]] | ||
[[Category: Han | [[Category: Han B]] | ||
[[Category: Ho | [[Category: Ho Y]] | ||
[[Category: Kley | [[Category: Kley N]] | ||
[[Category: Lin | [[Category: Lin J]] | ||
[[Category: Oh | [[Category: Oh A]] | ||
[[Category: Reynoids | [[Category: Reynoids DJ]] | ||
[[Category: Sharma | [[Category: Sharma G]] | ||
[[Category: Smith | [[Category: Smith CC]] | ||
[[Category: Wang | [[Category: Wang L]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Wang | [[Category: Wang Z]] | ||
[[Category: Yuen | [[Category: Yuen P]] | ||
[[Category: Zak | [[Category: Zak M]] | ||
[[Category: Zheng | [[Category: Zheng X]] | ||
Latest revision as of 16:25, 20 September 2023
Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
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