4v06: Difference between revisions
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==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain== | ==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain== | ||
<StructureSection load='4v06' size='340' side='right' caption='[[4v06]], [[Resolution|resolution]] 2.63Å' scene=''> | <StructureSection load='4v06' size='340' side='right'caption='[[4v06]], [[Resolution|resolution]] 2.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v06]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4v06]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V06 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v06 OCA], [https://pdbe.org/4v06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v06 RCSB], [https://www.ebi.ac.uk/pdbsum/4v06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v06 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] | |||
==See Also== | |||
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Burgess-Brown | [[Category: Burgess-Brown N]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Fitzpatrick F]] | ||
[[Category: Fitzpatrick | [[Category: Kiyani W]] | ||
[[Category: Kiyani | [[Category: Kopec J]] | ||
[[Category: Kopec | [[Category: Newman J]] | ||
[[Category: Newman | [[Category: Oberholzer A]] | ||
[[Category: Oberholzer | [[Category: Shrestha L]] | ||
[[Category: Shrestha | [[Category: Tallant C]] | ||
[[Category: Tallant | [[Category: Yue WW]] | ||
[[Category: Yue | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 10:38, 10 January 2024
Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
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