5a6r: Difference between revisions

<StructureSection load='5a6r' size='340' side='right'caption='[[5a6r]], [[Resolution|resolution]] 2.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[5a6r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A6R FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6r OCA], [https://pdbe.org/5a6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a6r RCSB], [https://www.ebi.ac.uk/pdbsum/5a6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6r ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KCD17_HUMAN KCD17_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/KCD17_HUMAN KCD17_HUMAN] Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).<ref>PMID:25270598</ref> <ref>PMID:25983243</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Bullock A]]

[[Category: Burgess-Brown NA]]

[[Category: Carpenter EP]]

[[Category: Chalk R]]

[[Category: Edwards AM]]

[[Category: Faust B]]

[[Category: Goubin S]]

[[Category: Kopec J]]

[[Category: Krojer T]]

[[Category: MacKenzie A]]

[[Category: Neshich I]]

[[Category: Newman JA]]

[[Category: Pearce NM]]

[[Category: Pike ACW]]

[[Category: Pinkas DM]]

[[Category: Quigley A]]

[[Category: Sanvitale CE]]

[[Category: Sorrell F]]

[[Category: Tallant C]]

[[Category: Williams E]]

[[Category: Von Delft F]]