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==Crystal structure of mouse cGAS in complex with 39 bp DNA==
==Crystal structure of mouse cGAS in complex with 39 bp DNA==
<StructureSection load='5n6i' size='340' side='right' caption='[[5n6i]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='5n6i' size='340' side='right'caption='[[5n6i]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5n6i]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6I FirstGlance]. <br>
<table><tr><td colspan='2'>[[5n6i]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N6I FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mb21d1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6i OCA], [https://pdbe.org/5n6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n6i RCSB], [https://www.ebi.ac.uk/pdbsum/5n6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6i OCA], [http://pdbe.org/5n6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6i RCSB], [http://www.ebi.ac.uk/pdbsum/5n6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.  
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n6i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n6i" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cyclic GMP-AMP synthase]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Andreeva, L]]
[[Category: Synthetic construct]]
[[Category: Hopfner, K P]]
[[Category: Andreeva L]]
[[Category: Kostrewa, D]]
[[Category: Hopfner K-P]]
[[Category: Activator dna]]
[[Category: Kostrewa D]]
[[Category: Cga]]
[[Category: Cyclic gmp-amp synthase]]
[[Category: Dna-binding]]
[[Category: Innate immune response]]
[[Category: Nucleotidyltransferase]]
[[Category: Pattern recognition receptor]]
[[Category: Transferase]]
[[Category: Viral dna recognition]]
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