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[[Image:2dun.jpg|left|200px]]


{{Structure
==Solution structure of BRCT domain of DNA polymerase mu==
|PDB= 2dun |SIZE=350|CAPTION= <scene name='initialview01'>2dun</scene>
<StructureSection load='2dun' size='340' side='right'caption='[[2dun]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DUN FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dun OCA], [https://pdbe.org/2dun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dun RCSB], [https://www.ebi.ac.uk/pdbsum/2dun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dun ProSAT], [https://www.topsan.org/Proteins/RSGI/2dun TOPSAN]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dun OCA], [http://www.ebi.ac.uk/pdbsum/2dun PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dun RCSB]</span>
[https://www.uniprot.org/uniprot/DPOLM_HUMAN DPOLM_HUMAN] Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.<ref>PMID:12640116</ref> <ref>PMID:12888504</ref> <ref>PMID:17483519</ref> <ref>PMID:17915942</ref>
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/2dun_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dun ConSurf].
<div style="clear:both"></div>


'''Solution structure of BRCT domain of DNA polymerase mu'''
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2DUN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUN OCA].
__TOC__
[[Category: DNA-directed DNA polymerase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Nagashima T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: 3 layers a/b/a]]
[[Category: national project on protein structural and functional analyse]]
[[Category: non-homologous end jonting]]
[[Category: nppsfa]]
[[Category: parallel beta-sheet of 4 strand]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: somatic hypermutation]]
[[Category: structural genomic]]
[[Category: v(d)j recombination]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:39:43 2008''
Retrieved from "https://proteopedia.org/2dun"