1kzd: Difference between revisions

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==Complex of MBP-C and GlcNAc-terminated core==
==Complex of MBP-C and GlcNAc-terminated core==
<StructureSection load='1kzd' size='340' side='right' caption='[[1kzd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1kzd' size='340' side='right'caption='[[1kzd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kzd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KZD FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rdo|1rdo]], [[1kza|1kza]], [[1kzb|1kzb]], [[1kzc|1kzc]], [[1kze|1kze]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzd OCA], [https://pdbe.org/1kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzd RCSB], [https://www.ebi.ac.uk/pdbsum/1kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzd OCA], [http://pdbe.org/1kzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kzd RCSB], [http://www.ebi.ac.uk/pdbsum/1kzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MBL2_RAT MBL2_RAT]] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).  
[https://www.uniprot.org/uniprot/MBL2_RAT MBL2_RAT] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1kzd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1kzd" style="background-color:#fffaf0;"></div>
==See Also==
*[[Mannose-binding protein|Mannose-binding protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Clark, D A]]
[[Category: Rattus norvegicus]]
[[Category: Drickamer, K]]
[[Category: Clark DA]]
[[Category: Feinberg, H]]
[[Category: Drickamer K]]
[[Category: Kolatkar, A R]]
[[Category: Feinberg H]]
[[Category: Ng, K K]]
[[Category: Kolatkar AR]]
[[Category: Park-Snyder, S]]
[[Category: Ng KK]]
[[Category: Weis, W I]]
[[Category: Park-Snyder S]]
[[Category: Immune system]]
[[Category: Weis WI]]
[[Category: Protein-carbohydrate complex]]
[[Category: Sugar binding protein]]
Retrieved from "https://proteopedia.org/1kzd"